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Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.
Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.
Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.

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Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Micro Crystalline CelluloseLibraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Product

Micro Crystalline Cellulose is a mechanically disintegrated level of D.P. Cellulose. It comprises purified, de-polymerised, Micro Crystalline sub micron size colloidal particles. It is produced by treating Alfa Cellulose obtained as a pulp from fibrous plants with minerals acid.

It is a white, odourless, tasteless, extra free flowing powder which is relatively free from organic and non-organic contaminants. It is metabolically inert, and has excellent water absorptive, swelling & dispersion properties, is insoluble in water, dilute acid, common organic solvents and oils. It is partially soluble in dilute alkali.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Brand

Micro Crystalline Cellulose is offered in ordinary non spray dried & spray dried directly compressible forms under the brand name LIBRAWCEL.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Process

Rayon Grade wood pulp, the main raw material is hydrolyzed under very carefully controlled conditions. After Hydrolysis, specific inclusion of hydrophobic agents is done. This is followed by thorogh washing with de-mineralised water. The depathogenised slurry prepared is pumped for Spray Drying and finally blended and packed.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Spray Drying

For the first time in India, Spray Dried Micro Crystalline Cellulose is being manufactured & offered to the customer at competitive prices. The Spray drier has been supplied and installed by M/s. ALFA Laval in technical collaboration with APV Pasilac Anhydro, A/S Denmark.

The atomization of the feed to be dried takes place concurrent to the drying air in a very robust atomizer revolving at an ultra high speed. The profile of temperatures in the drier can be adjusted to give optimum drying conditions. The feed to the atomizer is governed automatically by the temperature of the air. The powder is collected at two points.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Direct Compressible Grade

Librawcel, Direct Compressible Grade of Micro Crystalline Cellulose can be compressed into self - binding tablets, a boon for tablets manufacturers.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Advantages

Direct Compressible Grade of Micro Crystalline cellulose performs as an excipient to assist in the flow, lubrication and binding properties of the ingredients to be tableted and improves stability of durgs.
Facilitate rapid disintegration of the tablet.

It can be used in direct compression of most drugs and because of savings in material, capital, equipment and labour, it compensates the higher price of Direct Compressible Micro Crystalline Cellulose over non spray dried Micro Crystalline Cellulose.

The conventional costly method of tableting through 6 process steps is replaced by 2 steps direct compression method of tableting.

Detailed tests and investigations by various agencies for the use of Direct Compressible Grade Micro Crystalline Cellulose powder in tableting have shown:

¤ Excellent Compression & Hardness
¤ No Sign of Lubrication Difficulties
¤ Good Flowing Properties
¤ Reduces Friability & Weight Loss

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Librawcel Standards

.. Particle Size / Moisture Content
Grade Particle Size Standards Average Particle Size Moisture
Librawcel 101 +60 Mesh Not more than 1%
+200 Mesh Less than 30%
50 Micron 5
Librawcel 102 +60 Mesh Not more than 8%
+200 Mesh Less than 45%
100 Micron 5
Librawcel 103 +60 Mesh Not more than 1%
+200 Mesh Less than 30%
50 Micron 3

.. Microbiological Analysis
A Total microbial count - NMT 100 CFU
B Staphylococuus aureus negative
C Salmonella species negative
D E. coli negative

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Comparison chart of Specificatoins

Specifications I.P. U.S.P. B.P. Librawcel Average
Analysis Result
Tests
Identificatoin To Comply To Comply To Comply To Comply USP
PH 5.0 to 7.0 5.5 to 7.0 5.0 - 7.5 5.8 to 6.5
Loss on Drying NMT 5% NMT 5% NMT 6% 3.5 - 4.0
Water Soluble Substances Max. 0.16% Max. 0.16% Max. 0.2% Max. 0.12%
Residue on ignition NMT 0.2% NMT 0.05% NMT 0.1% Max. 0.05%
Heavy metals NMT 10ppm NMT 10ppm NMT 10ppm Max. 10ppm
Starch Negative Negative Negative Negative
Arsenic NMT 2ppm NMT 2ppm NMT 2ppm NMT 2ppm
Assay 97 - 102% 91 - 102% 91 - 102% 98.5 - 100%

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Quality Control

At Libraw, we believe in offering quality products at affordable prices. Precautions are taken right from the sourcing of raw material to the final packaging. The procurement of raw material is subjected to intense quality check before being accepted. We have an inbuilt system of analyzing the quality at various levels of production to ensure a consistent superior product. We have a very elaborate modern sophisticated laboratory where the final product is analysed for the detailed specification before it is cleared for despatch.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Microbiological Laboratory

Libraw Pharma has a modern Micro Biological Laboratory to conduct micro biological tests essential to make hygienic products.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Packing

Packing is done in pre laminated HDPE bags. Any modifications in packing can be suited to the customer need.

Librawcel is developed for the pharmaceutical industry where it has found extensive use as an excipient and diluent. It has replaced competitive products because of its uniqueness.

For instance - In tableting, Starch is a good disintegrate but a poor binder; Lactose is a good binder but a poor disintegrant. Spray Dried Micro Crystalline Cellulose is an excellent binder and a good disintegrant.

Non Spray Dried Micro Crystalline Cellulose, though less expensive than Spray Dried Micro Crystalline Cellulose, is less pure and has poor flow properties.

In some pharmaceutical tablet products, traces of inorganic impurities can markedly reduce drug stability and shelf life.

Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Librawcel - 102 Microcrystalline Cellulose, IP (Spray Dried)

Parameters Specification Result
Description Fine or Granular, White or almost White, Free flowing Powder, Odorless Free flowing, White powder Odorless
Solubility Insoluble in water slight soluble in dil. Sodium Hydroxide solution. It is insoluble in dil. Acids and most organic solvents. Complies
Identification
A Should comply Complies
B Should comply Complies
C Should comply Complies
pH 5 to 7.5 6.21
Starch and Dextrins Absent Absent
Organic Impurities Should Comply Complies
Water Soluble Substances % NMT 0.2 0.14
Arsenic, ppm NMT 2 Passes
Heavy Metal, ppm NMT 10 Passes
Sulphated Ash, % NMT 0.2 0.063
Loss on Drying % NMT 6 4
Assay, % Cellulose 97 - 102 99.42
In-House Specification*
Particle Size %
Wt. + 60 mesh NMT 8 Passes
Wt. +200 mesh NLT 45 Passes



Libraw Pharma - Manufacturer and Exporter of Binding Agent and Coating Polymers.Librawcel - W Microcrystalline Cellulose, IP (Bulk Dried)

Parameters Specification Result
Description Fine or Granular, White or almost White, Odorless Fine, White, Odorless Powder Complies
Solubility Insoluble in water slight soluble in dil. Sodium Hydroxide solution,insoluble in dil. Acids and most organic solvents & soluble in ammoniacal solution of copper tetra mine.
Indentification A, B & C Should comply Complies
B Degree of Polymerizatoin NMT 350 195
pH 5 to 7.5 6.39
Starch and Dextrins Absent Absent
Organic Impurities Should Comply Complies
Water Soluble Substances % NMT 0.2 0.1
Ether Soluble Sbustances NMT0.05 0.02
Arsenic, ppm NMT 2 Passes
Heavy Metal, ppm NMT 10 Passes
Sulphated Ash, % NMT 0.1 0.072
Loss on Drying % NMT 6 3.6
Assay, % Cellulose 97 - 102 99.7
In-House Specification*
Particle Size %
Wt. + 60 mesh NMT 1 Passes
Wt. +200 mesh NLT 30 Passes

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